(S,R,S)-AHPC-PEG2-C4-Cl
Based on 1 publication(s) in Google Scholar
(S,R,S)-AHPC-PEG2-C4-Cl (VH032-PEG2-C4-Cl) is a conjugate of ligands for E3 and 13-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG2-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and an alkyl/ether-based linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.
For research use only. We do not sell to patients.
- Purity: 98.12%
- CAS No.: 1835705-57-1
- Formula: C32H47ClN4O6S
- Molecular Weight:651.26
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) (S,R,S)-AHPC-PEG2-C4-Cl
MoreAll E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
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VHL |
(S,R,S)-AHPC-PEG2-C4-Cl uses the VHL ligand[1]. The linkers contain a mixture of hydrophobic and hydrophilic moieties to balance the hydrophobicity/hydrophilicity of the resulting hybrid compounds. PROTACs that induce the degradation of an oncogenic tyrosine kinase, BCR-ABL has been developed. (S,R,S)-AHPC-PEG2-C4-Cl can be attached to potent TKIs (bosutinib and dasatinib) that mediate the degradation of c-ABL and BCR-ABL by hijacking either CRBN or VHL E3 ubiquitin ligase[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1835705-57-1
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Appearance Oil
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Molecular Weight 651.26
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Formula C32H47ClN4O6S
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Color Light yellow to yellow
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SMILES
O=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCCCCCCl)=O)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2
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Synonyms
VH032-PEG2-C4-Cl; VHL Ligand-Linker Conjugates 7; E3 ligase Ligand-Linker Conjugates 10
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Structure
PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network. [Abstract]2024 Dec 5;32(12):2352-2363.e8. PMID: 39389062
Solvent & Solubility
DMSO : ≥ 50 mg/mL (76.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 50 mg/mL (76.77 mM; Need ultrasonic)
Ethanol : 50 mg/mL (76.77 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O / Ethanol | 1 mM | 1.5355 mL | 7.6774 mL | 15.3549 mL | 38.3871 mL |
| 5 mM | 0.3071 mL | 1.5355 mL | 3.0710 mL | 7.6774 mL | |
| 10 mM | 0.1535 mL | 0.7677 mL | 1.5355 mL | 3.8387 mL | |
| 15 mM | 0.1024 mL | 0.5118 mL | 1.0237 mL | 2.5591 mL | |
| 20 mM | 0.0768 mL | 0.3839 mL | 0.7677 mL | 1.9194 mL | |
| 25 mM | 0.0614 mL | 0.3071 mL | 0.6142 mL | 1.5355 mL | |
| 30 mM | 0.0512 mL | 0.2559 mL | 0.5118 mL | 1.2796 mL | |
| 40 mM | 0.0384 mL | 0.1919 mL | 0.3839 mL | 0.9597 mL | |
| 50 mM | 0.0307 mL | 0.1535 mL | 0.3071 mL | 0.7677 mL | |
| 60 mM | 0.0256 mL | 0.1280 mL | 0.2559 mL | 0.6398 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
(S,R,S)-AHPC-PEG2-C4-Cl Related Classifications
HY-103607 Related Classifications
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